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abalone haemocyanin
- Development stage
- Phase 2
- Lead developer
- Marine Biotechnology Australia
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Topical
01
Overview
Abalone haemocyanin is a marine-derived biologic protein extracted from the hemolymph of the Tasmanian abalone (*Haliotis rubra*). Developed by Marine Biotechnology Australia, it is being investigated as a topical antiviral treatment for herpes labialis (cold sores) caused by herpes simplex virus 1 (HSV-1). The drug functions by selectively binding to the viral surface glycoproteins gD, gB, and gC, thereby inhibiting viral attachment and entry into host cells. Unlike traditional antivirals that target post-entry replication, abalone haemocyanin acts as a viral entry inhibitor by likely mimicking cellular receptors. It is currently being evaluated in a randomized, double-blind, placebo-controlled proof-of-concept clinical trial as a once-daily topical formulation.
- Other names
- Haliotis rubra haemocyanin
02
Targets
gB (Human cytomegalovirus glycoprotein B)gC (Herpes simplex virus 1 glycoprotein C)gD (HSV-2 glycoprotein D)
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