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ABB

Development stage: Preclinical
Lead developer: ARTBIO
Modality: Alpha Emitters → Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Beta Emitters → Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration: Intravenous

Overview

ABB is an experimental alpha radioligand therapy (ART) being developed by ARTBIO. It utilizes Lead-212 (212Pb) as the radioactive isotope, which delivers potent alpha radiation to cancer cells. Alpha particles are characterized by high linear energy transfer and a short path length, allowing for the induction of complex DNA double-strand breaks while limiting damage to adjacent healthy tissues. ABB targets an undisclosed molecular marker and is part of ARTBIO's pipeline of 212Pb-based therapies for solid tumors. The program is based on the company's AlphaDirect platform, which aims to optimize the delivery and therapeutic window of alpha-emitting radiopharmaceuticals.

Other names: ARTBIO-undisclosed-alpha radioligand therapy (212Pb-based)212Pb-undisclosed

Targets

PSMA (Prostate-specific membrane antigen)

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