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ABCC1 siRNA
- Development stage
- Unknown
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous, Intratumoral
01
Overview
ABCC1 siRNA is a small interfering RNA (siRNA) designed to target and knock down the expression of the ABCC1 (ATP-binding cassette sub-family C member 1) gene, which encodes the multidrug resistance-associated protein 1 (MRP1). MRP1 is an efflux transporter that plays a critical role in mediating multidrug resistance in various cancers by pumping chemotherapeutic agents out of cells. By silencing ABCC1 expression, ABCC1 siRNA reduces MRP1 protein levels, thereby inhibiting drug efflux and restoring sensitivity to chemotherapeutic agents such as doxorubicin and vincristine in drug-resistant cancer cells. It is primarily utilized as a research-use-only laboratory tool to study multidrug resistance mechanisms and explore potential therapeutic strategies to overcome chemoresistance.
- Other names
- ABCC1 small interfering RNAABCC-1 small interfering RNAABCC 1 small interfering RNAMRP1 siRNAMRP-1 siRNAMRP 1 siRNAMRP1 small interfering RNAMRP-1 small interfering RNAMRP 1 small interfering RNAsi-ABCC1si-ABCC-1si-ABCC 1si-MRP1si-MRP-1si-MRP 1
02
Targets
ATP-binding cassette sub-family C member 1 messenger RNA
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