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ABD-0171

Development stage: Preclinical
Lead developer: Advanced BioDesign
Modality: Small Molecules

Overview

ABD-0171 is a second-generation small molecule inhibitor of aldehyde dehydrogenase (ALDH) currently in preclinical development by Advanced BioDesign. ALDH enzymes are known to be overexpressed in cancer stem cells (CSCs), where they contribute to metabolic plasticity, detoxification of reactive aldehydes, and resistance to conventional therapies. By inhibiting ALDH, ABD-0171 aims to deplete the CSC population and sensitize tumors to other treatments. The compound is specifically being investigated for the treatment of solid tumors, with a strategic focus on its use in combination with anti-PD-1 immune checkpoint inhibitors to overcome immune evasion and enhance therapeutic efficacy.

Targets

ALDH1A2 (Aldehyde dehydrogenase 1 family member A2)ALDH1A3 (Aldehyde dehydrogenase 1 family member A3)

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