Drug intelligence / Profile preview

Abdala ST

Development stage
Unknown
Lead developer
Center for Genetic Engineering and Biotechnology
Modality
Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes
Administration
Intramuscular
01

Overview

Abdala ST is a recombinant protein subunit vaccine developed by the Center for Genetic Engineering and Biotechnology (CIGB) in Cuba for the prevention of COVID-19. The vaccine is based on the Receptor Binding Domain (RBD) of the SARS-CoV-2 spike protein, which is expressed in the yeast *Pichia pastoris*. The "ST" designation refers to the "Sin Tiomersal" (thimerosal-free) formulation, developed to accommodate individuals with hypersensitivity to the preservative. It is typically administered as a three-dose intramuscular regimen and is adjuvanted with aluminum hydroxide. Abdala ST has received emergency use authorization and full regulatory approval in Cuba and several other nations, including Vietnam and Venezuela.

Brand names
Abdala
Other names
Abdala Sin TiomersalAbdala thimerosal-free
02

Targets

Angiotensin-converting enzyme 2 (ACE2)–Spike receptor-binding domain (RBD) protein–protein interfaceRBD (SARS-CoV-2 spike receptor-binding domain)

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