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abemaciclib + xentuzumab
- Development stage
- Unknown
- Lead developer
- Boehringer Ingelheim
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Oral
01
Overview
Abemaciclib + xentuzumab is a combination therapy consisting of abemaciclib, a CDK4/6 inhibitor, and xentuzumab, an insulin-like growth factor (IGF) ligand-neutralizing antibody. This combination targets two complementary pathways involved in cancer cell proliferation. Abemaciclib disrupts cell cycle progression by inhibiting CDK4/6, while xentuzumab neutralizes IGF ligands, preventing activation of the IGF pathway which leads to increased cyclin D1 expression. The dual inhibition approach aims to enhance anti-tumor efficacy, particularly in hormone receptor-positive (HR+), HER2-negative breast cancer.
- Brand names
- Verzenio
- Other names
- xentuzumab + abemaciclib
02
Targets
IGF-1 (Insulin-like growth factor 1)Cyclin-dependent kinase 2–cyclin A or E complexP-TEFb (Positive transcription elongation factor b)CDK5 (Cyclin-dependent kinase 5)CDK1 (Cyclin-dependent kinase 1)CDK4 (Cyclin-dependent kinase 4)Cyclin-dependent kinase 6–cyclin D1 complexIGF2 (Insulin-like growth factor 2)
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