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ABI-2280
- Development stage
- Phase 2
- Lead developer
- Antiva Biosciences
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Hydrogel Systems → Drug Delivery Systems
- Administration
- Topical, Vaginal
01
Overview
ABI-2280 is a small molecule, topical prodrug of an acyclic nucleoside phosphonate developed by Antiva Biosciences. It is designed as a vaginal insert for the treatment of high-grade cervical intraepithelial neoplasia (CIN 2,3) and persistent high-risk human papillomavirus (HPV) infection. The drug acts through a dual mechanism—directly inhibiting human intracellular DNA polymerases required for HPV replication and inducing apoptosis in HPV-infected cells while sparing normal cells. This targeted approach provides both anti-proliferative and antiviral effects across all genotypes of HPV[1][2][3][5][8].
- Other names
- acyclic nucleoside phosphonate prodrug
02
Targets
POLA1 (DNA polymerase alpha)
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