Drug intelligence / Profile preview

ABO2109 + toripalimab

Development stage
Unknown
Lead developer
Nanjing Drum-Tower Hospital
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Vaccines & Immunotherapeutics
Administration
Intramuscular, Intravenous
01

Overview

ABO2109 + toripalimab is a combination therapy consisting of a personalized cancer vaccine (ABO2109) and an immune checkpoint inhibitor (toripalimab). ABO2109 is a biological agent designed to elicit a patient-specific immune response against tumor neoantigens. Toripalimab is a humanized monoclonal antibody that targets the programmed cell death protein 1 (PD-1) receptor, blocking its interaction with PD-L1 and PD-L2 to enhance T-cell anti-tumor activity. This combination is being investigated by the Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School for the adjuvant treatment of patients with resected non-small cell lung cancer (NSCLC) to prevent recurrence by stimulating a robust, tumor-specific immune response.

Other names
ABO2109 and toripalimabABO-2109 and toripalimabABO 2109 and toripalimab
02

Targets

PDCD1 (Programmed cell death protein 1 receptor)Neoantigen-specific T-cell receptor

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