Drug intelligence / Profile preview

ABOR2013

Development stage: Phase 1
Lead developer: ABON Biopharm
Modality: mRNA Vaccines → Recombinant Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics, Cancer Vaccines → Therapeutic Vaccines → Vaccines & Immunotherapeutics, RNA Therapeutics → Nucleic Acid Therapeutics
Administration: Intramuscular

Overview

ABOR2013 is an investigational therapeutic mRNA vaccine designed to target specific mutations in the epidermal growth factor receptor (EGFR) gene commonly found in non-small cell lung cancer (NSCLC). The vaccine encodes for antigens corresponding to EGFR L858R, EGFR T790M, and EGFR exon 19 deletion mutations. Its mechanism involves inducing an immune response against tumor cells harboring these driver mutations. Developed by ABON Biopharm (Hangzhou), it is being evaluated as monotherapy or in combination with PD-1 monoclonal antibody therapy for advanced NSCLC with EGFR-positive mutations[1].

Targets

EGFR L858R (Epidermal growth factor receptor L858R mutant)EGFR T790M (Epidermal growth factor receptor T790M mutant)EGFR exon 19del (Epidermal growth factor receptor exon 19 deletion mutant)

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