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ABP 1019
- Development stage
- Unknown
- Lead developer
- Shanghai Aibo Pharmaceutical Technology
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
ABP 1019 is an orally bioavailable, small-molecule multi-target tyrosine kinase inhibitor (TKI) developed by Shanghai Aibo Pharmaceutical Technology. It is designed to inhibit a broad spectrum of kinases involved in tumor growth, angiogenesis, and metastasis, including Epidermal Growth Factor Receptor (EGFR), Fibroblast Growth Factor Receptors 1-4 (FGFR1-4), Vascular Endothelial Growth Factor Receptors 1-3 (VEGFR1-3), RET, and Platelet-Derived Growth Factor Receptor alpha (PDGFR-α). The drug is currently being evaluated in Phase I/II clinical trials for the treatment of various advanced solid tumors that have progressed on standard therapy, including glioma, pancreatic cancer, osteosarcoma, and small cell lung cancer, as well as brain metastases. Pharmacokinetic studies indicate a half-life of approximately 15–30 hours with linear pharmacokinetics.
- Other names
- ABP1019ABP-1019ABP 1019ABP1019AABP-1019AABP 1019A
02
Targets
VEGFR-1 (Vascular endothelial growth factor receptor 1)EGFR (Epidermal growth factor receptor)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)PDGFRA (Platelet-derived growth factor receptor alpha)FGFR2 (Keratinocyte growth factor receptor)RET (Rearranged during transfection receptor tyrosine kinase)FGFR4 (Fibroblast growth factor receptor 4)FGFR3 (Fibroblast growth factor receptor 3)FGFR1 (Fibroblast growth factor receptor 1)
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