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abp 980

Development stage: Phase 3
Lead developer: Amgen
Modality: Monoclonal Antibodies → Antibody-Based Therapeutics
Administration: Intravenous

Overview

ABP 980 is a biosimilar to trastuzumab (Herceptin), a recombinant DNA-derived humanized monoclonal immunoglobulin G1 kappa antibody that targets the human epidermal growth factor receptor 2 (HER2/ERBB2). It is developed for the treatment of HER2-positive breast cancer and gastric cancer. ABP 980 binds to the extracellular domain of HER2 and inhibits its signaling pathways, leading to inhibition of cell proliferation in tumors that overexpress HER2. The drug also mediates antibody-dependent cellular cytotoxicity (ADCC) against tumor cells. Clinical studies have demonstrated pharmacokinetic equivalence and no clinically meaningful differences in efficacy or safety compared with reference trastuzumab[5][6][7].

Brand names: KanjintiTrastuzumab-annsTrastuzumab beta
Other names: Herceptin biosimilartrastuzumab biosimilar 2

Targets

ERBB2 (Erb-b2 receptor tyrosine kinase 2)

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