absorbable gelatin sponge + thrombin

Absorbable gelatin sponge + thrombin is a **topical hemostatic combination** used to control bleeding during surgery, comprising an absorbable gelatin sponge (typically derived from porcine or bovine gelatin) and exogenous thrombin, most often bovine or recombinant human thrombin[1][3][5][6]. The gelatin sponge acts as a physical scaffold, absorbs blood, and provides a surface for platelet aggregation, facilitating clot formation by direct physical effects[1][2][3]. Thrombin, the key enzyme in hemostasis, catalyzes the conversion of fibrinogen to fibrin, thereby accelerating clot formation at the site of application[5][3]. When used together, the combination provides **dual mechanisms**: the gelatin sponge offers mechanical support for the clot, while thrombin enhances fibrin formation, resulting in rapid and stable hemostasis even in challenging surgical fields[3][5][6]. The product is **biodegradable** and is absorbed within weeks following application, with minimal tissue reaction[1][3]. The primary indications include surgical hemostasis in procedures such as spinal surgery, neurosurgery, general surgery, dental surgery, and ENT interventions[1][3][6]. This formulation is developed and manufactured by multiple companies, including Pfizer and Baxter, and is available in various branded forms[1][5][3].

Brand names

Gelfoam PlusThrombin-JMI with Absorbable Gelatin Sponge

Other names

absorbable gelatin sponge with thrombingelatin-thrombin hemostatic spongegelatin sponge loaded with thrombinthrombin-impregnated gelatin sponge