ABY-029

ABY-029 is a synthetic anti-EGFR (epidermal growth factor receptor) Affibody molecule conjugated to the near-infrared fluorescent dye IRDye 800CW. It consists of a 58-amino acid Affibody peptide (Z03115) that specifically binds EGFR and is used as an imaging agent for fluorescence-guided surgery. The drug enables real-time visualization of EGFR-expressing tumors during surgical resection by providing contrast between tumor and normal tissue. Developed for intravenous administration prior to surgery, it has demonstrated high correlation between fluorescence intensity and EGFR expression in clinical studies with soft-tissue sarcoma and head and neck cancers. No significant toxicity or adverse events have been reported in preclinical or early-phase human trials[1][5][6][8].

Brand names

ABY-029ABY029ABY 029

Other names

ABY-029 trifluoroacetate saltABY029 trifluoroacetate saltABY 029 trifluoroacetate saltfluorescently-labeled Anti-EGFR affibody moleculeIRDye 800CW maleimide-labeled affibody peptideIRDye800CW maleimide-labeled affibody peptideIRDye-800CW maleimide-labeled affibody peptide