AC-0027136

**AC-0027136** is an experimental small-molecule NeuroRestore compound originally developed by AlzeCure for cognitive impairment associated with Alzheimer's disease. In cell-based studies, it was identified as a positive modulator of nerve growth factor receptor TrkA and brain-derived neurotrophic factor receptor TrkB signaling. Preclinical studies reported improved mitochondrial metabolic activity and ATP production in primary cortical neurons, attenuation of scopolamine-induced memory impairment in mice, and improved long-term memory in aged animals. AC-0027136 has been described as a preclinical research compound related to, but distinct from, the NeuroRestore lead candidate ACD856. ([alzecurepharma.se](https://www.alzecurepharma.se/en/alzecure-gets-late-breaking-abstract-accepted-on-neurorestores-positive-effect-on-mitochondrial-function/))