Drug intelligence / Profile preview

acai seed extract

Development stage
Preclinical
Lead developer
Universidade Estadual do Rio de Janeiro
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Acai seed extract is a polyphenol-rich botanical substance derived from the seeds of the *Euterpe oleracea* Mart. palm, which are typically considered agro-industrial waste. Unlike the fruit pulp, which is high in anthocyanins, the seed extract is characterized by a high concentration of condensed tannins (procyanidins), catechin, and epicatechin. In the context of metabolic disorders such as obesity (DOID:9970), the extract demonstrates significant antioxidant, anti-inflammatory, and anti-dyslipidemic activities. Its mechanism of action involves the modulation of lipid metabolism, reduction of pro-inflammatory cytokines, and the enhancement of endothelial function through nitric oxide-dependent pathways. Research indicates that it may reduce weight gain, improve insulin sensitivity, and lower blood pressure in models of metabolic syndrome.

Other names
Euterpe oleracea seed extractAcai stone extract
02

Targets

NOS1 (nNOS)PPARA (Peroxisome proliferator-activated receptor alpha)PPARG (Peroxisome proliferator-activated receptor gamma)

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