Drug intelligence / Profile preview

acalypha australis

Development stage
Preclinical
Administration
Oral
01

Overview

**Acalypha australis** is a herbaceous annual plant in the family Euphorbiaceae, commonly known as Asian copperleaf or copperleaf. It is traditionally used in Chinese medicine for its purported effects on hemostasis (stopping bleeding), detoxification, heat clearance, and has historical usage for treating conditions like diarrhea, dysentery, snakebite, nosebleed, dermatitis, ulcerative colitis, and cough[1][2][3][5][6][7][8]. Pharmacological studies suggest its mechanisms may include anti-inflammatory effects (notably via NF-κB pathway inhibition), anti-obesity effects (through regulation of adipogenesis by suppressing PPARγ and CEBP/α expression), as well as possible antibacterial, antidiabetic, anticancer, and detoxifying actions[1][3][7]. Recent animal studies indicate potential benefit in mitigating ulcerative colitis and improving metabolic parameters related to obesity and lipid metabolism[1][3]. Its active constituents include flavonoids, with individual compounds such as 4-hydroxybenzoic acid methyl ester, 3-methoxy-4-hydroxybenzoic acid, and protocatechuic acid proposed to mediate some effects[1].

Other names
Asian copperleafcopperleafAcalypha australis L.AAL
02

Targets

PPARG (Peroxisome proliferator-activated receptor gamma)FABP4 (Fatty acid-binding protein 4)CEBPA (CCAAT enhancer-binding protein alpha)NF-κB

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