Drug intelligence / Profile preview

acalypha australis l. extract

Development stage
Preclinical
Administration
Oral
01

Overview

Acalypha australis L. extract is a **plant-derived extract** prepared from *Acalypha australis* and investigated in preclinical studies as a potential therapeutic or functional-food ingredient. Public literature describes mainly **aqueous or water-soluble extracts** that showed anti-obesity activity in high-fat-diet mouse and 3T3-L1 adipocyte models, where the extract reduced lipid accumulation and adipocyte differentiation, with reported downregulation of **PPARγ** and **C/EBPα** expression. Separate mouse studies in ulcerative colitis reported anti-inflammatory effects associated with reduced inflammatory cytokine release and inhibition of **NF-κB** pathway signaling. This is not an approved pharmaceutical with a defined single active moiety; rather, it is a heterogeneous botanical extract with mechanism inferred from preclinical pharmacology rather than a validated molecular target profile.

Other names
Acalypha australis L. extractAcalypha australis extractAAL extractAAL aqueous extractAAL water extractAcalypha australis L. water extract
02

Targets

PPARG (Peroxisome proliferator-activated receptor gamma)NF-κBCEBPA (CCAAT enhancer-binding protein alpha)

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