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Drug intelligence / Profile preview
acanthus ebracteatus
- Development stage
- Unknown
- Lead developer
- Center of Applied Thai Traditional Medicine
- Modality
- Small Molecules
- Administration
- Topical, Oral
01
Overview
*Acanthus ebracteatus*, commonly known as Holly Mangrove, is a medicinal mangrove species native to Southeast Asia and widely used in Thai traditional medicine. It is primarily utilized for the treatment of inflammatory skin conditions, wound healing, and as a neuroprotective agent. The therapeutic activity is attributed to various phytochemicals, including verbascoside (acteoside) and benzoxazolinone-type alkaloids. Research has demonstrated that extracts of *Acanthus ebracteatus* possess significant anti-inflammatory, antioxidant, and antimicrobial properties. In clinical and preclinical studies, it has been investigated as a topical treatment for atopic dermatitis, a component of combination therapies for acne vulgaris, and a potential treatment for androgenic alopecia due to its ability to inhibit 5-alpha reductase and promote dermal papilla cell proliferation.
- Other names
- holly mangrovesea hollyAcanthus ebracteatus Vahl
02
Targets
TOP2A (DNA topoisomerase II)MMP9 (Matrix metalloproteinase-9)NF-κBSRD5A (Steroid 5-alpha-reductase)
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