Drug intelligence / Profile preview

acarbose

Development stage
Approved
Lead developer
Bayer
Modality
Microbiome-Derived Products → Microbiome Therapeutics, Small Molecules
Administration
Oral
01

Overview

Acarbose is an oral anti-diabetic drug primarily used to manage type 2 diabetes mellitus. It acts as an alpha-glucosidase inhibitor, blocking enzymes (specifically intestinal alpha-glucosidases and pancreatic alpha-amylase) responsible for breaking down complex carbohydrates into glucose in the small intestine. By inhibiting these enzymes, acarbose slows carbohydrate digestion and absorption, reducing postprandial blood glucose spikes. It is typically prescribed alongside diet and exercise and may be combined with other diabetes medications or insulin. Acarbose is a complex oligosaccharide originally developed by Bayer[1][2][3][4][5][8].

Brand names
PrecoseGlucobayPrandase
Other names
O-4,6-Dideoxy-4-(((1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl)amino)-alpha-D-glucopyranosyl-(1-4)-O-alpha-D-glucopyranosyl-(1-4)-D-glucoseD-glucose, O-4,6-dideoxy-4-(((1S-(1 alpha,4 alpha,5 beta,6 alpha))-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl)amino)-alpha-D-glucopyranosyl-(1-4)-O-alpha-D-glucopyr anosyl-(1-4)-AcarbosaT58MSI464GT-58MSI464GT 58MSI464GDTXSID8046034DTXSID-8046034DTXSID 8046034RefChem:58795A10BF01A-10BF01A 10BF01DTXCID301508448DTXCID-301508448DTXCID 301508448O-4,6-Dideoxy-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-α-D-glucopyranosyl-(1→4)-O-α-D-glucopyranosyl-(1→4)-D-glucopyranose
02

Targets

AMY (Pancreatic alpha-amylase)Sucrase-Isomaltase

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