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ACAT-1 shRNA
- Development stage
- Preclinical
- Lead developer
- Southern Illinois University
- Modality
- Viral-delivered RNAi → In Vivo RNAi → Gene Silencing → Gene Therapies, RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intraperitoneal
01
Overview
ACAT-1 shRNA is a short hairpin RNA designed to silence the expression of the ACAT-1 (acyl-CoA:cholesterol acyltransferase 1) gene, also known as SOAT1. ACAT-1 is an enzyme responsible for the esterification of free cholesterol into cholesteryl esters, which are then stored in lipid droplets. In various cancers, including ovarian and endometrial cancer, ACAT-1 expression is often elevated, leading to increased cholesterol ester accumulation which may support tumor progression, migration, and invasion. By utilizing shRNA-mediated knockdown, researchers can investigate the therapeutic potential of inhibiting cholesterol metabolism as a strategy to suppress tumorigenesis and metastasis.
- Other names
- SOAT1 shRNASOAT-1 shRNASOAT 1 shRNAacyl-CoA cholesterol acyltransferase 1 short hairpin RNA
02
Targets
ACAT1 (Acyl-coenzyme A:cholesterol O-acyltransferase 1)DICER1 (Dicer ribonuclease III)XPO5 (Exportin-5)AGO2 (Argonaute RISC catalytic component 2)
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