Drug intelligence / Profile preview

acaudiolide

Development stage
Unknown
Lead developer
Nanjing University
01

Overview

acaudiolide: sourced facts only. name: "Integration of Connectivity Map (CMap) analysis with isotopic tandem orthogonal proteolysis-activity-based protein profiling (isoTOP-ABPP) chemical proteomics nominated SMAD4 as a candidate covalent target of acaudiolide." [PMID:42849690]; target: "Integration of Connectivity Map (CMap) analysis with isotopic tandem orthogonal proteolysis-activity-based protein profiling (isoTOP-ABPP) chemical proteomics nominated SMAD4 as a candidate covalent target of acaudiolide." [PMID:42849690]; developer: "State Key Laboratory of Pharmaceutical Biotechnology, Department of Hematology, Drum Tower Hospital Affiliated to Medical School, School of Life Sciences, Nanjing University, Nanjing, 210023, China." [PMID:42849690]; stage: "In a Western diet (WD)/CCl4 murine model of MASH, acaudiolide reduced collagen deposition, alpha-smooth muscle actin (α-SMA) expression and fibrogenic gene expression." [PMID:42849690]

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