Drug intelligence / Profile preview

AccuLNP CRISPR formulation

Development stage
Preclinical
Lead developer
NanoTech Pharma
Modality
Gene Editing → Gene Therapies, Gene Addition/Replacement → Gene Therapies, Gene Silencing → Gene Therapies, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
01

Overview

AccuLNP CRISPR formulation is a lipid nanoparticle (LNP) based delivery system designed for the efficient transfection of nucleic acids, including messenger RNA (mRNA) and CRISPR/Cas9 ribonucleoproteins (RNPs), into cells. It utilizes advanced LNP technology to encapsulate these genetic components, facilitating their entry into target cells for various applications such as gene editing and the development of novel mRNA therapies. The formulation is available in versions optimized for both in vitro and in vivo use, demonstrating high transfection efficiency and low cytotoxicity across diverse cell lines. It acts as a crucial vehicle for enabling CRISPR/Cas9-mediated gene editing by delivering the Cas9 nuclease and guide RNA complex, which then precisely targets and cleaves specific DNA sequences, allowing for gene knock-out, knock-in, or correction.

Brand names
AccuLNP
Other names
AccuLNP Transfection Reagent KitAccuLNP Cell Transfection KitAccuLNP in vivo versionAccuLNP in vitro version
02

Targets

Genomic DNA target sequence

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