Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
ACE-86225106
- Development stage
- Phase 2
- Lead developer
- Acerand Therapeutics
- Modality
- Classical Binding Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
ACE-86225106 is a novel, oral, and highly selective small molecule inhibitor of poly (ADP-ribose) polymerase 1 (PARP1), developed by Acerand Therapeutics. It is being investigated as an antineoplastic agent for the treatment of advanced solid tumors, including breast cancer, ovarian cancer, and prostate cancer. The drug acts by inhibiting PARP1, a key enzyme involved in DNA repair pathways; this mechanism can lead to synthetic lethality in tumor cells with defects in homologous recombination repair such as those harboring BRCA mutations. Preclinical studies have shown significant inhibitory effects on PARP1 with potentially reduced hematological toxicity compared to earlier pan-PARP inhibitors. As of April 2024, ACE-86225106 is undergoing Phase I/II clinical trials primarily in China[1][3][6].
- Other names
- Selective PARP1 Inhibitor
02
Targets
PARP1 (Poly (adp-ribose) polymerase 1)
Beyond the preview
Go deeper on ACE-86225106.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on ACE-86225106.