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ACE2-mesenchymal stem cells
- Development stage
- Unknown
- Lead developer
- Capital Medical University
- Modality
- Gene Therapies, Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous
01
Overview
ACE2-mesenchymal stem cells are genetically engineered mesenchymal stem cells that overexpress angiotensin-converting enzyme 2, typically generated by lentiviral transduction of bone marrow-derived or umbilical cord-derived MSCs. This investigational **cell therapy** is being studied mainly for severe inflammatory lung disease such as COVID-19 pneumonia, acute lung injury, and acute respiratory distress syndrome. The therapeutic rationale is to enhance local ACE2 activity within the renin-angiotensin system, promoting conversion of angiotensin II to angiotensin 1-7 and thereby reducing inflammation, vascular permeability, cell death, and cytokine-driven lung damage. Available public information points to academic clinical development in China, including work at Beijing YouAn Hospital of Capital Medical University, rather than a clearly identified commercial branded product.
- Other names
- ACE2-MSCsACE-2-MSCsACE 2-MSCsACE2-overexpressing mesenchymal stem cellsACE-2-overexpressing mesenchymal stem cellsACE 2-overexpressing mesenchymal stem cellsACE2 gene-modified mesenchymal stem cellsACE-2 gene-modified mesenchymal stem cellsACE 2 gene-modified mesenchymal stem cells
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