Drug intelligence / Profile preview

ACE2016 + pembrolizumab

Development stage
Preclinical
Lead developer
Merck
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics
Administration
Intravenous
01

Overview

ACE2016 + pembrolizumab is a combination therapy that includes ACE2016, an investigational biologic, and pembrolizumab, an FDA-approved humanized IgG4 monoclonal antibody against programmed death 1 (PD-1). Pembrolizumab acts as a checkpoint inhibitor, blocking the PD-1/PD-L1 interaction to enhance anti-tumor T cell responses[3]. ACE2016 is a code name that may correspond to a pipeline biologic or antibody therapeutic, though no public clinical trial or regulatory record specifically defining ACE2016 could be confidently identified; thus, it is almost certainly an experimental therapeutic paired with pembrolizumab in clinical investigation or preclinical research. Pembrolizumab is most commonly indicated and approved for use in multiple malignancies, either alone or in combination regimens, and developed by Merck (MSD outside North America)[1][2][3].

Other names
lambrolizumabACE2016ACE-2016ACE 2016
02

Targets

PDCD1 (Programmed cell death protein 1 receptor)

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