aceclidine

Aceclidine is a direct-acting cholinergic small molecule used as an ophthalmic miotic. It functions primarily as a muscarinic receptor agonist on the iris sphincter and ciliary muscle, producing pupillary constriction that can improve near vision through a pinhole effect in presbyopia. Historically it has also been studied as an antiglaucoma miotic and was noted in older literature to induce less accommodative spasm than pilocarpine in some patients. More recently, LENZ Therapeutics developed aceclidine ophthalmic solution 1.44% as the monotherapy product LNZ100, which was commercialized in the United States as VIZZ for presbyopia; the same active ingredient has also been studied in combination with brimonidine as LNZ101 for presbyopia.

Brand names

VIZZ

Other names

aceclidine