Drug intelligence / Profile preview

aceclofenac + paracetamol + cetirizine + phenylephrine + caffeine

Development stage
Unknown
Lead developer
Bernard Biotech
Modality
Small Molecules
Administration
Oral
01

Overview

Acoydase-Cold is a multi-ingredient oral symptomatic cold formulation developed by Bernard Biotech. It is designed to provide comprehensive relief from symptoms associated with the common cold, influenza, and allergic rhinitis. The formulation combines five active pharmaceutical ingredients: aceclofenac, a non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce pain and inflammation; paracetamol, an analgesic and antipyretic that provides additional pain relief and fever reduction; cetirizine hydrochloride, a second-generation antihistamine that antagonizes H1 receptors to alleviate allergic symptoms like sneezing and runny nose; phenylephrine hydrochloride, a decongestant that acts as an alpha-1 adrenergic receptor agonist to reduce nasal congestion; and caffeine, which serves as a mild stimulant and adenosine receptor antagonist, often used to enhance the analgesic effects of the other components and counteract drowsiness.

Brand names
Acoydase-Cold
Other names
Aceclofenac, Paracetamol, Cetirizine Hydrochloride, Phenylephrine Hydrochloride, Caffeine
02

Targets

ADORA2A (Adenosine A₂A Receptor)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)HRH1 (Histamine H1 Receptor)ADORA1 (Adenosine receptor A1 subtype)ADRA1A (α1A)PGHS-1 (Prostaglandin G/H Synthase 1)

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