aceclofenac + paracetamol + serratiopeptidase

This oral fixed-dose combination product developed by Kriam Pharma contains aceclofenac, paracetamol, and serratiopeptidase. Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase enzymes (COX-1 and COX-2), thereby reducing the production of prostaglandins involved in pain and inflammation. Paracetamol serves as an analgesic and antipyretic, likely acting through central COX inhibition and modulation of endogenous cannabinoid pathways to elevate the pain threshold. Serratiopeptidase is a proteolytic enzyme derived from Serratia species that facilitates the breakdown of abnormal proteins such as fibrin and bradykinin at the site of injury. This enzymatic action helps reduce edema, improve microcirculation, and accelerate tissue repair. The combination is indicated for the symptomatic management of pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, and post-traumatic or post-operative edema.

Brand names

KRIAM-SP

Other names

Aceclofenac, Paracetamol, and Serratiopeptidase combination