acellular adipose tissue

Acellular adipose tissue, also known as acellular adipose matrix (AAM), is a biologically derived scaffold created by removing cellular components and lipids from human or animal adipose (fat) tissue while preserving the native extracellular matrix (ECM) structure and associated growth factors. The resulting product contains structural proteins such as collagen type I, collagen type IV, laminin, and various bioactive molecules that support cell adhesion, proliferation, angiogenesis, and in vivo induction of new fat cell formation (adipogenesis). AAM is used primarily for soft tissue reconstruction in settings such as congenital defects, trauma repair, cancer care reconstruction, or cosmetic procedures. When implanted or injected into the body, AAM serves as a scaffold for host cells—especially stem cells—to migrate into the site and regenerate new soft tissue with improved volume retention compared to traditional autologous fat grafting. Because it lacks living cells or immunogenic material from donors after processing, AAM reduces risks of immune rejection and necrosis seen with conventional grafts[1][4][5][6]. Research supports its safety profile and effectiveness in promoting soft-tissue regeneration; however clinical data are still limited.

Other names

acellular adipose matrixAAMadipose tissue-derived extracellular matrixallograft adipose matrix