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acemannan
- Development stage
- Unknown
- Lead developer
- Carrington Laboratory
- Administration
- Oral, Topical, Intralesional, Intraperitoneal, Intravenous
01
Overview
Acemannan is a highly acetylated mannan polysaccharide derived from Aloe vera, specifically Aloe barbadensis Miller. It is the primary bioactive component in Aloe vera gel and consists of D-isomer mucopolysaccharides linked by β-(1,4) glycosidic bonds. Acemannan exhibits immunomodulatory, antiviral, antitumor, osteogenic, anti-inflammatory, and antibacterial properties. Mechanistically, it induces cytokine production (including interferon gamma, tumor necrosis factor-alpha, and interleukins), activates macrophages via Toll-like receptor 5 (TLR5)/NF-kB signaling pathways in gingival fibroblasts, and promotes tissue repair through AKT/mTOR-mediated protein translation. Clinically investigated for oral diseases such as aphthous ulcers and candidiasis (e.g., Celagace Orarinse Solution), it also shows potential for wound healing and bone regeneration[1][2][3][5][6]. In veterinary medicine it has been used to manage fibrosarcoma in dogs and cats[5].
- Brand names
- CarrisynCello gelSnow & sun sports gel
- Other names
- Poly Acetyl MannosePoly Acetylated Mannans
02
Targets
TLR2 (Toll-like Receptor 2)TLR5
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