acetaminophen + diphenhydramine hydrochloride

Pain Relief PM is an over-the-counter (OTC) fixed-dose combination medication containing the non-opioid analgesic acetaminophen (paracetamol) and the first-generation antihistamine diphenhydramine hydrochloride. Acetaminophen acts primarily in the central nervous system to inhibit prostaglandin synthesis via cyclooxygenase (COX-1 and COX-2) inhibition, thereby relieving minor aches and pains. Diphenhydramine hydrochloride acts as an inverse agonist at central histamine H1 receptors, crossing the blood-brain barrier to induce drowsiness and promote sleep. This combination is indicated for the temporary relief of occasional headaches and minor aches and pains accompanied by sleeplessness.

Brand names

GoodSense Extra Strength Pain Relief PMH-E-B Extra Strength Pain Relief PMHealth Star Night Time Pain ReliefKroger Extra Strength Pain Reliever PMMapap PMNotts Pain Relief PMPain Relief PMPercogesic Extra StrengthRight Remedies Extra Strength PM Pain ReliefTylenol PMUnisom PM PainValuMeds Pain Relief PM

Other names

acetaminophen + diphenhydramineacetaminophen + diphenhydramine HClacetaminophen + diphenhydramine hydrochlorideacetaminophen and diphenhydramineacetaminophen and diphenhydramine HClacetaminophen and diphenhydramine hydrochlorideacetaminophen/diphenhydramineacetaminophen/diphenhydramine HClacetaminophen/diphenhydramine hydrochloride