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acetaminophen + tramadol (Thrift Pharmaceuticals)
- Development stage
- Phase 4
- Lead developer
- Thrift Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Intravenous, Oral
01
Overview
Nacra is a brand of analgesic medications marketed by Thrift Pharmaceuticals. It is available in two distinct formulations: Nacra injection, which contains tramadol hydrochloride as a single active ingredient, and Nacra tablets, which is a fixed-dose combination of acetaminophen (paracetamol) and tramadol hydrochloride. Tramadol is a centrally acting synthetic opioid analgesic and a serotonin-norepinephrine reuptake inhibitor (SNRI), while acetaminophen is a non-opioid analgesic and antipyretic. Together, these formulations are used for the management of moderate to severe pain.
- Brand names
- NacraUltracet
- Other names
- acetaminophen + tramadol hydrochlorideparacetamol + tramadolparacetamol + tramadol hydrochloride
02
Targets
MOR (Mu opioid receptor)NET (Norepinephrine Transporter)SERT (Sodium-dependent serotonin transporter)PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)TRPV1 (Transient receptor potential cation channel subfamily V member 1)
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