acetaminophen + aspirin + caffeine

Acetaminophen + aspirin + caffeine is an oral fixed-dose combination analgesic used to treat mild to moderate pain such as tension headaches and migraine. It contains three active ingredients: - Acetaminophen (paracetamol), an analgesic and antipyretic that reduces pain and fever by acting on the central nervous system. - Aspirin (acetylsalicylic acid), a non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase enzymes to reduce inflammation and pain. - Caffeine is a central nervous system stimulant that acts as an adenosine receptor antagonist; it enhances the analgesic effects of acetaminophen and aspirin while also helping relieve headache symptoms. This triple combination has been shown to be more effective than any of its individual components or dual combinations for acute headache relief. The product is available over-the-counter in many countries under various brand names. Chronic or excessive use can increase risks of hepatotoxicity (from acetaminophen), gastrointestinal bleeding (from aspirin), renal papillary necrosis with long-term high doses of both acetaminophen and aspirin together; caffeine may cause insomnia or palpitations in sensitive individuals[1][2][3][4].

Brand names

Excedrin Extra StrengthExcedrin MigraineBayer Migraine FormulaVanquishGoody's Extra StrengthGoody's Headache PowdersAnacin Advanced Headache FormulaArthritenBackaid IPFPamprin MaxBC MAX STRENGTH Fast Pain ReliefMelabon KNeuralgin Classic

Other names

acetaminophen-aspirin-caffeine drug combinationaspirin/paracetamol/caffeine combination