Drug intelligence / Profile preview

acetaminophen + aspirin + caffeine (Prestige Consumer Healthcare)

Development stage
Phase 4
Lead developer
Prestige Consumer Healthcare
Modality
Small Molecules
Administration
Oral
01

Overview

Goody's Powder (also known as Goody's Headache Powders) is an over-the-counter combination pain reliever containing acetaminophen, aspirin, and caffeine. It is formulated as a fast-dissolving single-dose powder, which allows for rapid absorption and faster onset of action compared to traditional tablets or capsules. Goody's Powder is primarily used for the temporary relief of minor aches and pains associated with headaches, migraines, muscle aches, backaches, toothaches, and common colds. The combination works synergistically: aspirin and acetaminophen act as analgesics and antipyretics by inhibiting cyclooxygenase (COX) enzymes and reducing prostaglandin synthesis, while caffeine acts as an adenosine receptor antagonist and central nervous system stimulant that enhances the analgesic efficacy of the pain relievers.

Brand names
Acamol FocusAnadin ExtraAntinevralgic ForteAntinevralgic PArthritenBayer Migraine FormulaCitramonDolomoDolopyrin ALExcedrinExcedrin Extra StrengthExcedrin Menstrual CompleteExcedrin MigraineExidolGenacedGoody PowderGoody'sGoody's Extra StrengthGoody's Headache PowdersGoody's Migraine ReliefGrand-PaHA-TablettenInfluASSMelabon KNeuralginPain Reliever PlusPamprin MaxParamol TargetratiopyrinThomapyrinThomapyrin ClassicThomapyrin IntensivVanquish
Other names
acetaminophen + aspirin + caffeineacetaminophen, aspirin, and caffeineacetylsalicylic acid + paracetamol + caffeineacetylsalicylic acid, paracetamol, and caffeineaspirin + paracetamol + caffeineaspirin, paracetamol, and caffeineparacetamol + aspirin + caffeineparacetamol, aspirin, and caffeine
02

Targets

ADORA1 (Adenosine receptor A1 subtype)ADORA2A (Adenosine A₂A Receptor)PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)

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