Drug intelligence / Profile preview

acetaminophen + chlorpheniramine + dextromethorphan + pseudoephedrine

Development stage
Unknown
Lead developer
Zhejiang Kangde Pharmaceutical Group
Modality
Small Molecules
Administration
Oral
01

Overview

An Fen Ma Mei is a fixed-dose combination pharmaceutical product developed and manufactured by Zhejiang Kangde Pharmaceutical, specifically formulated as a dry suspension for pediatric use. It is indicated for the relief of symptoms associated with the common cold and influenza in children, including fever, headache, limb pain, sneezing, runny nose, nasal congestion, and cough. The formulation combines four active ingredients: acetaminophen (an antipyretic and analgesic), pseudoephedrine hydrochloride (a nasal decongestant), dextromethorphan hydrobromide (a cough suppressant), and chlorpheniramine maleate (an antihistamine). By targeting multiple pathways—including prostaglandin synthesis, adrenergic receptors, histamine receptors, and the medullary cough center—it provides comprehensive symptomatic relief for upper respiratory tract infections.

Brand names
An Fen Ma Mei
Other names
Anfen MameiAnfen Mamei MinPediatric Paracetamol, Pseudoephedrine Hydrochloride, Dextromethorphan Hydrobromide and Chlorpheniramine Maleate Dry Suspension
02

Targets

SERT (Sodium-dependent serotonin transporter)HRH1 (Histamine H1 Receptor)PGHS-1 (Prostaglandin G/H Synthase 1)ADRA1A (α1A)GRIN1 (NMDA receptor subunit 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)ADRA1B (α1B)SIGMAR1 (Sigma non-opioid intracellular receptor 1)

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