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acetaminophen + gabapentin + ketamine + bupivacaine
- Development stage
- Preclinical
- Lead developer
- Pfizer
- Modality
- Small Molecules
- Administration
- Oral, Intravenous, Local Injection, Epidural, Intrathecal, Rectal, Intramuscular, Intranasal
01
Overview
A multimodal analgesic combination that utilizes four different medications with complementary mechanisms of action. Acetaminophen provides general pain relief and fever reduction. Gabapentin treats neuropathic pain by modulating calcium channels. Ketamine is an NMDA receptor antagonist that blocks pain pathways to the brain. Bupivacaine is a local anesthetic that blocks nerve signals. This combination approach may provide enhanced pain control while potentially reducing the need for opioid analgesics.
02
Targets
COXNMDAR (Glutamate receptor ionotropic, NMDA)NaV (Voltage-gated sodium channels)CACNA2D1 (Voltage-gated calcium channel subunit alpha2/delta-1)
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