Drug intelligence / Profile preview

acetaminophen + ibuprofen (Pfizer)

Development stage
Approved
Lead developer
Johnson & Johnson
Modality
Small Molecules
Administration
Oral
01

Overview

**Advil Dual Action with Acetaminophen** is an oral fixed-dose, over-the-counter analgesic product containing acetaminophen 250 mg and ibuprofen 125 mg per caplet. Ibuprofen is a nonselective cyclooxygenase inhibitor that reduces peripheral prostaglandin synthesis, while acetaminophen provides centrally mediated analgesia through mechanisms that are not fully resolved. The Haleon product is used for temporary relief of minor pain, including headache, toothache, backache, menstrual cramps, muscular aches, and minor arthritis pain. ([advil.com](https://www.advil.com/our-products/advil-pain/advil-dual-action/))

Brand names
Advil Dual ActionAdvil Dual Action with Acetaminophen
Other names
acetaminophen + ibuprofenacetaminophen/ibuprofenibuprofen + acetaminophenibuprofen/acetaminophenparacetamol + ibuprofenparacetamol/ibuprofen
02

Targets

PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)

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