acetaminophen + N-acetylcysteine

Acetaminophen + N-acetylcysteine is a combination of two small molecule drugs. Acetaminophen (also known as paracetamol) is an analgesic and antipyretic widely used for pain relief and fever reduction. N-acetylcysteine (NAC) is an antioxidant and glutathione precursor that serves as the standard antidote for acetaminophen overdose, protecting against drug-induced hepatotoxicity by replenishing hepatic glutathione stores and directly binding toxic metabolites of acetaminophen. Co-formulation or co-administration of these agents has been shown in preclinical models to prevent liver toxicity associated with high doses of acetaminophen, suggesting a potential public health benefit if used together in over-the-counter products to reduce the risk of accidental or intentional overdose[2][3]. The combination leverages the therapeutic effects of acetaminophen while mitigating its primary safety risk—liver damage—through NAC’s protective mechanism.

Other names

APAP and NAC combinationacetaminophen and N-acetylcysteine combinationAPAP + NAC