acetaminophen + naproxen + gabapentin + oxycodone + tramadol

This combination is a multi-modal pain regimen (MMPR) consisting of acetaminophen, naproxen, gabapentin, oxycodone, and tramadol. It is utilized as the standard of care for managing acute pain in trauma patients, specifically within clinical research conducted by The University of Texas Health Science Center, Houston. The regimen employs a multi-mechanistic approach to analgesia: acetaminophen and naproxen inhibit prostaglandin synthesis via cyclooxygenase (COX) enzymes; gabapentin modulates voltage-gated calcium channels to reduce excitatory neurotransmitter release; and oxycodone and tramadol provide potent analgesia through mu-opioid receptor agonism. Tramadol additionally contributes to pain relief by inhibiting the reuptake of serotonin and norepinephrine. This specific combination was used as the control arm in the DOPE trial (NCT03928015) to evaluate the efficacy of adjunct dronabinol in reducing opioid consumption.

Other names

acetaminophen + naproxen + gabapentin + oxycodone + tramadol-The University of Texas Health Science Center, Houston-painMulti-Modal Pain RegimenMMPR