Drug intelligence / Profile preview

acetaminophen + naproxen sodium

Development stage
Unknown
Lead developer
Johnson & Johnson
Modality
Small Molecules
Administration
Oral
01

Overview

Acetaminophen + naproxen sodium is a combination of two analgesic drugs used to relieve mild to moderate pain and reduce fever. Acetaminophen acts primarily as an analgesic and antipyretic by inhibiting the release of substances in the brain that cause pain sensation, though its precise mechanism is not fully understood. Naproxen sodium is a nonsteroidal anti-inflammatory drug (NSAID) that works by blocking the formation of prostaglandins, substances responsible for inflammation and pain. This combination provides both anti-inflammatory effects (from naproxen) and central pain relief (from acetaminophen), making it useful for conditions such as headaches, muscle aches, menstrual cramps, arthritis, toothaches, sore throats, and other sources of mild to moderate pain[1][5][8].

Brand names
Proxalin-PlusDonixal GesicFarxenFebradol Extra ForteFebraxFebroxanFiverdolFlaxenolMafidol CompuestoNaprocop CompuestoNaprofebrilNaprol Extra ForteNaprophar DuoNaproxen/Paracetamol (generic)Naproxeno + Paracetamol (Spanish)Naprosyn-PNedoxalNeorpan PlusNeuralgesicNomax DolOnexmol DuoPensodilPromizem DuoQuilnax DuoSupramass ForteTedraxUlpafie-nVelsay-S CompuestoXenoplusXenorac
Other names
naproxen sodium + acetaminophen
02

Targets

PGHS-1 (Prostaglandin G/H Synthase 1)COX POX site (Prostaglandin-endoperoxide synthase 1 (COX-1) peroxidase site)

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