acetaminophen + pamabrom + pyrilamine maleate

acetaminophen + pamabrom + pyrilamine maleate is an over-the-counter combination medication used for the temporary relief of menstrual symptoms, including cramps, headache, backache, bloating, muscle pain, water-weight gain, and irritability[1][2][3][4][5][6]. It contains three active ingredients: - **Acetaminophen** is a pain reliever and antipyretic that works primarily by inhibiting prostaglandin synthesis in the central nervous system, reducing pain impulse generation and regulating body temperature via the hypothalamus[1][2][3][4][5]. - **Pamabrom** is a mild diuretic that increases urine output and helps reduce water retention and bloating[1][2][3][4][5]. - **Pyrilamine maleate** is a first-generation H1 histamine receptor antagonist (antihistamine) that reduces the effects of histamine, helps alleviate irritability with sedative properties, and may induce mild drowsiness[1][2][3][4][5]. This combination is not intended for use in children under 12, and its use is contraindicated in patients with allergy to any of the components, severe hepatic/renal impairment, or recent treatment with monoamine oxidase inhibitors[1][2][5][6].

Brand names

Midol Maximum Strength PMSPamprin Multi-Symptom Maximum StrengthPremsyn PMSPamprin Max Pain FormulaGNP Pre-Menstrual Relief Max StrengthMenstrual Pain ReliefMenstrual PMSRA Menstrual Pain Relief

Other names

acetaminophen/pamabrom/pyrilamineacetaminophen + pamabrom + pyrilamine