acetaminophen + tranexamic acid

This combination regimen consists of acetaminophen, a non-opioid analgesic and antipyretic, and tranexamic acid, a synthetic antifibrinolytic agent. It is being evaluated by the University of California, Davis, as part of an Enhanced Recovery After Surgery (ERAS) protocol for patients undergoing elective lumbar spine surgery. Acetaminophen is utilized to manage postoperative pain, primarily through the inhibition of prostaglandin synthesis in the central nervous system. Tranexamic acid is administered to reduce surgical blood loss by competitively inhibiting the activation of plasminogen to plasmin, thereby stabilizing fibrin clots. The specific clinical trial (NCT04446429) compares the efficacy and cost-effectiveness of oral versus intravenous administration of these preoperative medications to optimize surgical outcomes and resource utilization.

Brand names

Ofirmev

Other names

Oral vs IV Preoperative Medications in Spine Surgery ERASacetaminophen and tranexamic acid