acetarsol

Acetarsol is a pentavalent organic arsenical compound with antiprotozoal and anthelmintic properties. Discovered in 1921 by Ernest Fourneau at the Pasteur Institute, it was marketed under the brand name Stovarsol. Acetarsol has been used to treat a range of protozoal and parasitic infections including syphilis, amoebiasis, yaws, trypanosomiasis, malaria, Trichomonas vaginalis vaginitis, Candida albicans infections (vaginitis), intestinal amoebiasis (oral form), and refractory proctitis (suppository form). Its mechanism of action is not fully understood but is thought to involve binding to protein sulfhydryl groups in parasites to form lethal arsenic-sulfur bonds. The drug was withdrawn from the market in 1997 due to safety concerns related to arsenic toxicity[1][2][4].

Brand names

Stovarsol

Other names

N-acetyl-4-hydroxy-m-arsanilic acidN-acetyl4-hydroxy-m-arsanilic acidN-acetyl 4-hydroxy-m-arsanilic acidN-acetyl-4-hydroxy-m-arsinillic acidN-acetyl4-hydroxy-m-arsinillic acidN-acetyl 4-hydroxy-m-arsinillic acid97-44-9