acetazolamide + dexamethasone

Acetazolamide + dexamethasone (specifically the brand combination Diamox and DexaEDO) is a preoperative treatment regimen used in patients with glaucoma undergoing trabeculectomy. Acetazolamide is a potent carbonic anhydrase inhibitor that reduces intraocular pressure (IOP) by decreasing the secretion of aqueous humor. Dexamethasone is a synthetic glucocorticoid used for its anti-inflammatory properties. In the clinical trial context led by Katrin Lorenz, this combination is administered preoperatively to stabilize IOP and reduce ocular surface inflammation, with the specific goal of minimizing the risk of postoperative filtration failure caused by scarring of the filtration bleb. The regimen typically involves oral administration of acetazolamide and topical application of preservative-free dexamethasone eye drops.

Brand names

DexaEDO

Other names

Diamox + DexaEDOacetazolamide + dexamethasone