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**Acetic acid + propylene glycol** is a nonaqueous otic solution formulated with 2% acetic acid in a propylene glycol vehicle (including propylene glycol diacetate, benzethonium chloride, and sodium acetate)[1][3][6][8]. It is primarily used for the treatment of superficial infections of the external auditory canal (otitis externa) caused by organisms susceptible to its antimicrobial action[1][3][6]. **Acetic acid** acts as an antibacterial and antifungal agent. **Propylene glycol** functions as a hydrophilic solvent, reducing surface tension to facilitate contact with tissues, and enhances drug absorption and distribution. The solution is buffered at pH 3 and designed for topical administration to the ear canal[1][3][6][8].
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