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Acetyl-L-carnitine + folic acid is a combination therapy being investigated for the treatment of male primary infertility. Acetyl-L-carnitine (ALC) is an ester of the amino acid L-carnitine that plays a crucial role in energy metabolism by transporting long-chain fatty acids into the mitochondria for beta-oxidation. In the context of male fertility, ALC is thought to improve sperm motility and provide antioxidant protection against oxidative stress. Folic acid (Vitamin B9) is essential for DNA synthesis and repair, and its supplementation is associated with improved sperm count and quality. This specific combination is being studied by Khyber Medical University Peshawar to evaluate its effects on semen parameters, hormonal levels, and oxidative status compared to other antioxidant combinations like Coenzyme Q10 and folic acid.
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