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ACH-0142684
- Development stage
- Discontinued
- Lead developer
- Alexion Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
ACH-0142684 (also known as ACH-2684) is an investigational small molecule inhibitor of the Hepatitis C virus (HCV) NS3 protease. Developed by Achillion Pharmaceuticals, it was designed as a second-generation protease inhibitor with potent activity in the low picomolar range against multiple HCV genotypes and common resistance-associated variants. The compound was evaluated in Phase 1 clinical trials, including pharmacokinetic drug-drug interaction studies alongside the NS5A inhibitor ACH-3102 (ACH-0143102). Development of ACH-0142684 was ultimately discontinued as Achillion shifted its strategic focus toward complement factor D inhibitors and the HCV market became dominated by highly effective all-oral combination therapies.
- Other names
- Deldeprevir
02
Targets
NS3/4A (Hepatitis C virus nonstructural protein 3/4A serine protease)
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