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ACHN-383 + ACHN-789
- Development stage
- Unknown
- Lead developer
- Achaogen
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
ACHN-383 + ACHN-789 is an **oral combination drug** investigated under the code name **C-Scape**. This combination includes two novel agents: **ACHN-383**, a beta-lactam antibiotic, and **ACHN-789**, a beta-lactamase inhibitor. The combination is designed to overcome the resistance mechanisms in extended spectrum beta-lactamase (ESBL) producing Enterobacteriaceae by inhibiting beta-lactamase enzymes and providing robust antibacterial activity. Primary clinical focus is on the treatment of infections caused by multidrug-resistant Gram-negative bacteria. The initial clinical studies—such as Phase 1 studies—have focused on safety, tolerability, pharmacokinetics, food effect, and drug-drug interactions in healthy subjects, including those with renal impairment. The developer is Achaogen.
- Other names
- C-Scape
02
Targets
β-lactamasePBP (Penicillin-binding protein family)
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