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ACI-15916
- Development stage
- Unknown
- Lead developer
- AC Immune
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
**ACI-15916** is a radiopharmaceutical and diagnostic agent developed by AC Immune SA. It acts as a modulator of monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B), but its primary clinical application is as a positron emission tomography (PET) tracer for detecting abnormal protein deposits, specifically α-synuclein, in the brain. This makes it relevant for diseases such as Parkinson’s disease, Lewy body dementia, and multiple system atrophy—collectively known as α-synucleinopathies. The drug is currently being evaluated in early-phase clinical trials to assess its safety and effectiveness in measuring pathological α-synuclein accumulation[1][3][8].
- Other names
- fluorine-18 ACI-15916fluorine18 ACI-15916fluorine 18 ACI-15916
02
Targets
aggregated α-syn (Alpha-synuclein (α-syn))
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