acitretin + total glucosides of paeony

Acitretin + total glucosides of paeony is a combination therapy used primarily for the treatment of moderate-to-severe plaque psoriasis and other forms of psoriasis. Acitretin is a second-generation oral retinoid that modulates keratinocyte differentiation and proliferation, thereby reducing the hyperproliferation characteristic of psoriatic lesions. Total glucosides of paeony (TGP) are active glycoside compounds extracted from the roots of Paeonia lactiflora Pall., traditionally used in Chinese medicine for their anti-inflammatory and immunomodulatory effects. TGP has been shown to inhibit inflammatory cytokine production, modulate immune cell function, and reduce hepatotoxicity associated with conventional systemic therapies. Clinical studies indicate that this combination enhances anti-psoriatic efficacy compared to acitretin alone while reducing adverse events such as liver enzyme elevation[1][2][7]. The combination is generally well-tolerated and may be particularly beneficial in patients at risk for hepatic side effects.

Other names

TGP + acitretin